November 5th

6–9 pm
Speaker Reception and Dinner at the Washington Duke Inn (by invitation only)

November 6

Lecture Hall, Searle Center, Duke University Medical Center (map)

The Searle Conference Center at Duke University Medical Center is at 10 Searle Center Drive, Durham, NC 27710. Searle Center Drive is directly off of Research Drive.

7:30-8:00 AM
Registration (free to all), coffee, juice, bagels
8:00-8:15 AM
Welcome and Opening remarks
Co-Chairs: P. Murali Doraiswamy, MBBS, FRCP, and Joanne Kurtzberg, MD
Distinguished Duke Alumnae Leader and Philanthropist: Marjorie Bekaert Thomas, CEO, Ivanhoe Broadcast News
8:15-8:50 AM
Unmet Needs in Alzheimer’s disease
Duke University:
P. Murali Doraiswamy, MBBS, FRCP

The global threat of Alzheimer’s disease
Keck School of Medicine of USC:
Lon Schneider, MD

Current Therapies- What have we learned from failures?
Group discussion moderated by Dr. Doraiswamy
8:50-9:15 AM
Karen L. Wrenn Keynote Address (25 minutes)
Mahendra Rao, MD, PhD
Where are the current bottlenecks in regenerative medicine?
9.15-9:30 AM
Group discussion – Moderated by Dr. Kurtzberg
9:30-9:40 AM
Short break or time to make up.
9:40-10:55 AM
Novel approaches towards investigating disease phenotypes
University of California, San Diego:
Larry Goldstein, PhD

Evaluating AD phenotypes in patient-derived iPSCs
Columbia University:
Chris Henderson, PhD

In vitro and in vivo approaches to investigate pathological mechanisms to identify novel therapeutic targets for neurodegenerative diseases
Johns Hopkins:
Akira Sawa MD, PhD

Multifaceted approach involving neuropsychology, brain imaging, and human stem cell biology to investigate neuropsychiatric conditions
Group discussion – Moderated by Dr. Hunsberger
10:55-11:15 AM
11:15-12:30 PM
Cell Therapy Approaches for Alzheimer’s Disease
Alexandra Capela, PhD, StemCells Inc.
Translational research activities using adult-derived human neural stem cells
Jeff Bulte, PhD, Johns Hopkins
Non-invasive, high-resolution cell tracking for stem cell therapy
Frank LaFerla, PhD, UC Irvine
Neural stem cell therapy
Group discussion – Moderated by Min Cho PhD, Nature Neuroscience
12:30-1:45 PM
Lunch, Networking, & 3D Printing Demonstrations
1:45-3:15 PM
Major National and State Initiatives (15min talks)
Duke Stem Cell and Cellular Therapy:
Joanne Kurtzburg, MD

Duke’s capabilities, progress, and vision for cell therapy in AD
Major National Initiatives in Regenerative Medicine:
Anthony Atala, MD
California Institute for Regenerative Medicine:
Ellen G. Feigal, MD

Overview of progress made in regenerative medicine with 8 projects totaling over $26 Million in support.
New York Stem Cell Foundation:
Stephen Chang, PhD

The NYSCF Alzheimer’s disease team: developing collections and resources for drug discovery
Group discussion – Dr. Kurtzberg (30mins)
3:15-3:35 PM
3:35-5:20 PM
IND Enabling Studies for AD: Addressing new technologies to pave the way forward towards the clinic
Moderator: Mahendra Rao, MD, PhD
Panel Discussion with experts:
Thomas Finn, PhD, Food and Drug Administration
Hank Greely, JD, Stanford
And invited speakers
5:20-5:30 PM
Concluding remarks by Co-Chairs